GameBiz: How many hours of gameplay do you envision for Titan Quest? A single play-through of Titan Quest should take about 25 – 30 hours to finish, depending on how much you explore and how many side quests you complete. However, there are three difficulty levels, which include un-lockable bosses and unique powerful items, which we think will make it worth your time to play a bit longer. Not to mention trying the game with at least a few different combination classes!