MMORPG.com:

How will people who own both games be able to get missions in the new areas? For example, are there contacts in Paragon City that are only available to people with both games?

David "Zeb" Cook:

There are several ways to have missions in the new areas. CoV players will sometimes have contacts who send them on special instanced missions in Paragon City, so they can be in hero territory but at the same time not introduce disruptive PvP play. As we introduce new content for CoH, there is always the possibility of being sent on similar missions in the Rogue Isles. This would not be a case of needing to have CoV. In addition there will also be hero and villain missions set in the PvP zones.